Proposal to adopt Proposition 65 Maximum Allowable Dose Levels (MADLs) for n-hexane. The proposed oral MADL for n-hexane is 28,000 micrograms per day and the proposed inhalation MADL for n-hexane is 20,000 micrograms per day.
Proposition 65, officially known as the Safe Drinking Water and Toxic Enforcement Act of 1986, was enacted as a ballot initiative in November 1986. The proposition protects the state's drinking water sources from being contaminated with chemicals known to cause cancer, birth defects or other reproductive harm, and requires businesses to inform Californians about exposures to such chemicals.
Proposition 65 requires the state to maintain and update a list of chemicals known to the state to cause cancer or reproductive toxicity.
This proposed regulatory action would amend subsection (a) to clarify that where a business presents evidence for the “level in question” of a chemical listed as causing reproductive toxicity in a food product based on the average of multiple samples of that food, the level in question may not be calculated by averaging the concentration of the chemical in food products from different manufacturers or producers, or that were manufactured in different facilities from the product at issue.
The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) intends to list bevacizumab as known to the state to cause reproductive toxicity (developme